研究方向：

承担的主要科研项目

先后主持承担了国家973项目、公益性行业（农业）科研专项、国家科技支撑计划、杰出青年科学基金项目、国家食品安全重大科技专项、国家自然科学基金重点项目、农业部残留专项及国家农业行业标准制修订项目等40余项。

研究成果

2015年获国家技术发明二等奖（第1完成人）

2014年获湖南省科技进步一等奖（第2完成人）

2013年获中华农业科技奖科学研究成果一等奖（第1完成人）

2013年获中华农业科技奖优秀创新团队（第1完成人）

2006年获国家科学技术进步二等奖（第1完成人）

2005年获北京市科学技术一等奖（第1完成人）

2001年获北京市科技进步二等奖（第1完成人

近年发表的主要文章：

1.Yiyun Liu, Yang Wang, Timothy R Walsh, Lingxian Yi, Rong Zhang, James Spencer, Yohei Doi, Guobao Tian, Baolei Dong, Xianhui Huang, Linfeng Yu, Danxia Gu, Hongwei Ren, Xiaojie Chen, Luchao Lv, Dandan He, Hongwei Zhou, Zisen Liang, Jianhua Liu*, Jianzhong Shen*. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. The Lancet Infectious Diseases. 2015, doi:10.1016/S1473-3099(15)00424-7

2.Yang Wang, Yuan Lv, Jiachang Cai, Stefan Schwarz, Lanqing Cui, Zhidong Hu, Rong Zhang, Jun Li, Qin Zhao, Tao He, Dacheng Wang, Zheng Wang, Yingbo Shen, Yun Li, Andrea T. Fessler, Congming Wu, Hao Yu, Xuming Deng, Xi Xia, Jianzhong Shen*. A novel gene, optrA, that confers transferable resistance to oxazolidinones and phenicols and its presence in Enterococcus faecalis and Enterococcus faecium of human and animal origin. Journal of Antimicrobial Chemotherapy, 2015, 70(8), 2182-2190

3.Wenxiao Jiang, Natalia V Beloglazova, Zhanhui Wang, Haiyang Jiang, Kai Wen, Sarah de Saeger, Pengjie Luo, Yongning Wu, Jianzhong Shen*. Development of a multiplex flow-through immunoaffinity chromatography test for the on-site screening of 14 sulfonamide and 13 quinolone residues in milk. Biosensors and Bioelectronics. 2015, 66, 124-128

4. Li, J., B. Li, S. Wendlandt, S. Schwarz, Y. Wang, C. Wu, Z. Ma, and J. Shen*. 2014. Identification of a novel vga(E) gene variant that confers resistance to pleuromutilins, lincosamides and streptogramin A antibiotics in staphylococci of porcine origin. J Antimicrob Chemother 69:919-923.

5. Liu, Y., Y. Wang, S. Schwarz, S. Wang, L. Chen, C. Wu, and J. Shen*. 2014. Investigation of a multiresistance gene cfr that fails to mediate resistance to phenicols and oxazolidinones in Enterococcus faecalis. J Antimicrob Chemother 69:892-898.

6. Qin, S., Y. Wang, Q. Zhang, M. Zhang, F. Deng, Z. Shen, C. Wu, S. Wang, J. Zhang, and J. Shen*. 2014. Report of ribosomal RNA methylase gene erm(B) in multidrug-resistant Campylobacter coli. J Antimicrob Chemother 69:964-968.

7. Wang, Y., X. Wang, S. Schwarz, R. Zhang, L. Lei, X. Liu, D. Lin, and J. Shen*. 2014. IMP-45-producing multidrug-resistant Pseudomonas aeruginosa of canine origin. J Antimicrob Chemother 69:2579-2581.

8. Wang, Y., M. Zhang, F. Deng, Z. Shen, C. Wu, J. Zhang, Q. Zhang, and J. Shen. 2014. Emergence of Multidrug-Resistant Campylobacter Species Isolates with a Horizontally Acquired rRNA Methylase. Antimicrob Agents Chemother 58:5405-5412.

9. Jianzhong Shen, Yang Wang, and Stefan Schwarz. Presence and dissemination of the multiresistance gene cfr in Gram-positive and Gram-negative bacteria. J Antimicrob Chemother. 2013, 68: 1697-1706.

10. Wenxiao Jiang, Zhanhui Wang, Ross C. Beier, Haiyang Jiang, Yongning Wu, Jianzhong Shen*. Simultaneous determination of 13 fluoroquinolone and 22 sulfonamide residues in milk by a dual-colorimetric enzyme-linked immunosorbent assay. Analytical Chemistry. 2013, 85(4), 1995-1999

11. Wang Zhanhui, Li Na, Zhang Suxia, Zhang Huiyan, Sheng Yajie, Shen Jianzhong*. Production of antibodies and development of enzyme-linked immunosorbent assay for valnemulin in porcine liver. Food Additives and Contaminants. 2013, 30(2), 244-252

12. Liu Yang, Wang Yang, Schwarz Stefan, Li Yun, Shen Zhangqi, Zhang Qijing, Wu Congming, Shen Jianzhong*. Transferable multiresistance plasmids carrying cfr in Enterococcus spp. from swine and farm environment. Antimicrobial Agents and Chemotherapy. 2013, 57(1), 42-48

13. Wang Yang, Wang Yu, Schwarz Stefan, Shen Zhangqi, Zhou Nan, Lin Juchun, Wu Congming, Shen Jianzhong*. Detection of the staphylococcal multiresistance gene cfr in Macrococcus caseolyticus and Jeotgalicoccus pinnipedialis. Journal of Antimicrobial Chemotherapy. 2012, 67(8), 1824-1827

14. Li Hui, Xia Xi, Xue Yanan, Tang Shusheng, Xiao Xilong, Li Jiancheng, Shen Jianzhong*. Simultaneous determination of amoxicillin and prednisolone in bovine milk using ultra-high performance liquid chromatography tandem mass spectrometry. Journal of Chromatography B. 2012, 900, 59-63

15. Wen Kai, Nölke G, Schillberg S, Wang Zhanhui, Zhang Suxia, Wu Congming, Jiang Haiyang, Meng Hui, Shen Jianzhong*. Improved fluoroquinolone detection in ELISA through engineering of a broad-specific single-chain variable fragment binding simultaneously to 20 fluoroquinolones. Analytical and Bioanalytical Chemistry. 2012, 403(9), 2771-2783

16. Zhu Kui, Li Jiancheng, Wang Zhanhui, Jiang Haiyang, Beier Ross C, Xu Fei, Shen Jianzhong*, Ding Shuangyang*. Simultaneous detection of multiple chemical residues in milk using broad-specificity antibodies in a hybrid immunosorbent assay. Biosensors and Bioelectronics. 2011, 26(5), 2716-2719

17. Wang Zhanhui, Zhang Jing, Zhang Suxia, Shen Jianzhong*. Heterologous structure of coating antigen on sensitivity of ELISA for sulfamethazine: evidence from molecular similarity analysis.  Food and Agricultural Immunology. 2011, 22(2), 115-124

18. Xi Xia, Yichun Dong, Pengjie Luo, Xia Wang, Xiaowei Li, Shuangyang Ding, Jianzhong Shen*. Determination of benzimidazole residues in bovine milk by ultra-high performance liquid chromatography–tandem mass spectrometry. Journal of Chromatography B. 2010, 878(30), 3174-3180

19. Dai Lei, Wu Congming, Wang Minggui, Wang Yang, Wang Yu, Huang Siyang, Xia Lining, Li Beibei, Shen Jianzhong*. First report of the multidrug resistance gene cfr and the phenicol resistance gene fexA in a Bacillus strain from swine feces. Antimicrobial Agents and Chemotherapy. 2010, 54(9), 3953-3955

20. Xia Xi, Li Xiaowei, Ding Shuangyang, Shen Jianzhong. Validation of a method for the determination of chloramphenicol in poultry and swine liver by ultra-performance liquid chromatography coupled with tandem mass spectrometry. Journal of AOAC International. 2010, 93(5), 1666-1671

21. Wang Zhanhui, Zhu Yan, Ding Shuangyang, He Fangyang, Beier R C, Li Jiancheng, Jiang Haiyang, Feng Caiwei, Wan Yuping, Zhang Suxia, Kai Zenpeng, Yang Xinling, Shen Jianzhong*. Development of a monoclonal antibody-based broad-specificity elisa for fluoroquinolone antibiotics in foods and molecular modeling studies of cross-reactive compounds. Analytical Chemistry. 2007, 79(12), 4471-4483